Sameera Reddy's sister Sushma and . She graduated from Sydenham College.

Sameera Reddy popular with Pankaj Udhas music video Aahista. Video of her, she in college.

Her first venture into Bollywood opposite Sohail Khan in Maine Dil Tujko Guardia (2002).
Although the film did not do very well, bringing recognition actress.
Sameera Reddy has not several of his films in the south, one of exalted Telugu superstar.

Both were a huge hit. She also made with the renowned Bengali director Buddhadev Dasgupta film Kalpurush. Kalpurush may be her best work so far, her performance than even the worst of her critics by surprise.